Endocrine Abstracts

Introduction: Diabetogenic effect limits the use of glucocorticoids (GC).Aim: To evaluate the role of modified HOMA-IR and HOMA-islet indices in different carbohydrate metabolism disorders (CMD) during oral (OGCT) and PULSE (GCPT) glucocorticoid therapy (GCT).Patients and methods: A study including 165 patients with systemic lupus erythematosus (n=53), systemic vasculitis (n=45) and chronic glomerulonephritis (<em...

Introduction: Glucocorticoid therapy (GCT) is one of the risk factors of carbohydrate metabolism disorders (CMD) in patents with systemic inflammatory diseases. CMD development is a concern not only with long-term therapy, but also during intensive short-term glucocorticoid (GC) administration, which can lead to different CMDs, including impaired glucose tolerance (IGT) and diabetes mellitus (DM).Aim: To evaluate the prevalence of CMD after long-term and...

Background and aims: To study the need for insulin during pregnancy, depending on the duration of the disease.Methods: We studied 108 pregnant women with DM 1 receiving insulin with insulin pumps. Patients were divided into three groups: in the 1st group diabetes duration was less than 5 years, in the 2nd – 5 to 15 years, 3rd – more than 15 years. We evaluated the daily need for insulin on 12, 22–25, 30–32 weeks of gestation.<p cl...

Aim: To investigate the possible association of the rs9939609 polymorphism in the FTO gene with obesity in the Republic of Tatarstan (RT).Materials and methods: The study involved 63 adult patients (21 men and 42 women; 38–77 years old) with overweight or obesity and 515 healthy young people (157 men and 358 women; 16–35 years old) with normal weight. We assessed clinical and biochemical parameters (blood lipid profile). The analysis of the rs9...

Aim: To investigate the possible association of the FTO gene rs9939609 polymorphism with different disorders of carbohydrate metabolism in residents of the Republic of Tatarstan.Materials and methods: A total of 237 patients with a single history of hyperglycemia were examined. They underwent an oral glucose tolerance test on a BS-200E Mindray analyzer. 198 patients from the whole cohort had various disorders of carbohydrate metabolism, so they were incl...

Aim: To investigate the effect of the standard dietary recommendations in diabetes mellitus type 2 to the intensity of metabolic processes due to different variants of polymorphism rs1801282 Pro12Ala of the PPARG gene.Materials and methods: 37 patients (11 men and 26 women) in the age of 38–76 years old (the mean age 56.8±9.55 y.o.), with the verified diagnosis of diabetes mellitus type 2 (the mean duration of illness 5.7±3.59 years) and t...